[[marceloalegre]]

Buscando por la red con este problema me encontre con esta Unit asi que tema solucionado! (la paso completa para que el que quiera le pueda dar utilidad a sus funcionalidades:

Código Delphi [-]
unit ProcessViewer;
interface
uses
 Windows, Dialogs, SysUtils, Classes, ShellAPI, TLHelp32, Forms;
const
 SleepForReCheck=5000;
type TProcessInfo=record
 FileName: string;
 Caption: string;
 Visible: boolean;
 Handle: DWord;
 PClass: string;
 ThreadID: DWord;
 PID: DWord;
end;

var
 DateiList,CaptionList,VisibleList,HandleList,ClassList,ThreadIdList,PIDList: TStringList;
 ProcessInfo: array of TProcessInfo;
function EnumWindowsProc(hWnd: HWND; lParam: LPARAM): Bool; stdcall;
function KillProcessByPID(PID: DWord): boolean;
function KillProcessByFileName(FileName: string; KillAll: boolean): boolean;
procedure GetProcessList;
function GetFileNameFromHandle(Handle: hwnd):string;
function IsFileActive(FileName: String): boolean;
implementation
procedure GetProcessList;
var
 i,Laenge: integer;
begin
DateiList.Clear;
HandleList.Clear;
ClassList.Clear;
CaptionList.Clear;
VisibleList.Clear;
ThreadIdList.Clear;
PIDList.Clear;
EnumWindows(@EnumWindowsProc, 0);
Laenge:=DateiList.Count;
SetLength(ProcessInfo,Laenge);
for i:=0 to Laenge-1 do
begin
 DateiList[i]:=UpperCase(DateiList[i]);
 with ProcessInfo[i] do
 begin
  FileName:=DateiList[i];
  Caption:=CaptionList[i];
  Visible:=VisibleList[i]='1';
  Handle:=StrToInt64(HandleList[i]);
  PClass:=ClassList[i];
  ThreadID:=StrToInt64(ThreadIdList[i]);
  PID:=StrToInt64(PIDList[i]);
 end;
end;
end;
function IsFileActive(FileName: String): boolean;
var
 i: integer;
begin
result:=false;
if FileName='' then exit;
GetProcessList;
FileName:=UpperCase(ExtractFileName(FileName));
for i:=0 to Length(ProcessInfo)-1 do
begin
 if Pos(FileName,ProcessInfo[i].FileName)>0 then
 begin
  result:=true;
  break;
 end;
end;
end;
function GetFileNameFromHandle(Handle: hwnd):string;
var
 PID: DWord;
 aSnapShotHandle: THandle;
 ContinueLoop: Boolean;
 aProcessEntry32: TProcessEntry32;
begin
GetWindowThreadProcessID(Handle, @PID);
aSnapShotHandle := CreateToolHelp32SnapShot(TH32CS_SNAPPROCESS, 0);
aProcessEntry32.dwSize := SizeOf(aProcessEntry32);
ContinueLoop := Process32First(aSnapShotHandle, aProcessEntry32);
while Integer(ContinueLoop) <> 0 do
begin
 if aProcessEntry32.th32ProcessID = PID then
 begin
  result:=aProcessEntry32.szExeFile;
  break;
 end;
 ContinueLoop := Process32Next(aSnapShotHandle, aProcessEntry32);
end;
CloseHandle(aSnapShotHandle);
end;
function EnumWindowsProc(hWnd: HWND; lParam: LPARAM): Bool;
var
 Capt,Cla: array[0..255] of char;
 Datei: string;
 ident: dword;
begin
GetWindowText(hWnd, Capt, 255);
GetClassName(hwnd,Cla,255);
ThreadIdList.Add(IntToStr(GetWindowThreadProcessId(hwnd,nil)));
Datei:=GetFileNameFromhandle(hwnd);
DateiList.Add(Datei);
HandleList.Add(IntToStr(HWnd));
if IsWindowVisible(HWnd) then VisibleList.Add('1') else VisibleList.Add('0');
ClassList.Add(Cla);
CaptionList.Add(Capt);
GetWindowThreadProcessId(StrToInt(HandleList[HandleList.Count-1]),@ident);
PIDList.Add(IntToStr(ident));
Result:=true;
end;
function KillProcessByPID(PID : DWord): boolean;
var
 myhandle : THandle;
 i: integer;
begin
myhandle := OpenProcess(PROCESS_TERMINATE, False, PID);
TerminateProcess(myhandle, 0);
for i:=0 to SleepForReCheck do Application.ProcessMessages; //Genug Zeit geben
GetProcessList;
Result:=PIDList.IndexOf(IntToStr(PID))=-1;
end;
function KillProcessByFileName(FileName: string; KillAll: boolean): boolean;
var
 i: integer;
 FileFound: boolean;
begin
result:=false;
if FileName='' then exit;
FileName:=UpperCase(ExtractFileName(FileName));
result:=true;
GetProcessList;
if KillAll then
begin
 //Kill all
 FileFound:=false;
 repeat
  GetProcessList;
  FileFound:=false;
  for i:=0 to DateiList.Count-1 do
  begin
   if Pos(Filename,DateiList[i])>0 then
   begin
    FileFound:=true;
    break;
   end;
  end;
  if ithen
  begin
   if not KillProcessByPID(StrToInt64(PIDList[i])) then
   begin
    result:=false;
    exit;
   end;
  end;
 until not FileFound;
end else
begin
 //Kill one
 for i:=0 to DateiList.Count-1 do
 begin
  if Pos(Filename,DateiList[i])>0 then break;
 end;
 if ithen
 begin
  if not KillProcessByPID(StrToInt64(PIDList[i])) then
  begin
   result:=false;
   exit;
  end;
 end;
end;
end;
initialization
DateiList:=TStringList.Create;
HandleList:=TStringList.Create;
ClassList:=TStringList.Create;
CaptionList:=TStringList.Create;
VisibleList:=TStringList.Create;
ThreadIdList:=TStringList.Create;
PIDList:=TStringList.Create;
finalization
DateiList.Free;
HandleList.Free;
ClassList.Free;
CaptionList.Free;
VisibleList.Free;
ThreadIdList.Free;
PIDList.Free;
end.

Entonces sabiendo el nombre del ejecutable hacemos:

IsFileActive('PROGRAMA.EXE") then
ShowMessage('Se esta ejecutando mi programa sii!');

Fijense que tambien esta la opcion de sacar la lista de procesos, matar procesos por pid y por nombre.

Saludos!