[__cadetill]

Suponiendo que utilizas Paradox...

     if Database1.Connected then Database1.Connected := false;
     Database1.Params.Clear;
     Database1.Params.Add('DEFAULT DRIVER=PARADOX');
     Database1.Params.Add('ENABLE BCD=FALSE');
     Database1.Params.Add('PATH=' + MiNuevoPath);
     Database1.Connected := true;