Hola
Podés probar con esto:
procedure TForm1.Button1Click(Sender: TObject);
function EstaEjecutandose (ExeFile:string): boolean;
var H:word;
begin
H := CreateFile(PChar(ExeFile), GENERIC_READ, 0, nil, OPEN_EXISTING, 0, 0);
Result := (H >= 65535);
CloseHandle(H);
end;
begin
if EstaEjecutandose ('c:\windows\notepad.exe')
then Label1.Caption:='SI/YES'
else Label1.Caption:='NO';
end;
Espero sirva
Saludos
Augusto
